Season 21

At 14, Melanie is introduced to crack cocaine by an older boyfriend; she is instantly hooked and ends up in rehab at 15.

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Chelan was a devoted wife and mother until the breakup of her marriage sent her spiraling into the world of prescription opioid abuse; three years later, Chelan is homeless, works as a prostitute and is no longer allowed to see her three little boys.

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When she was a teenager, Courtney's moodiness turned to rebellion and she began to experiment with drugs; now, she no longer cares about her health or safety.

Coleman began experimenting with alcohol and drugs after his father died; his drug use caused him to lose custody of his 4-year-old daughter; his family worries his addiction may kill him.

Shandon's early life was disrupted at 3 years old when her parents divorced and her mother moved out of the country; now in her mid-20s and saddled with a $200-a-day intravenous habit, she prostitutes herself to feed her addiction.

Natasha's new life after her parents' divorce contains alcohol- and drug-fueled parties, and she later begins using harder drugs like crystal meth and heroin; now a full-blown addict at 22, Natasha has a chance to start her life over.